Ornithine carbamoyltransferase (Q420678)

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mammalian protein found in Homo sapiens

• OTCase
• OTC
• ornithine transcarbamylase
• ornithine carbamoyltransferase, mitochondrial

edit

Language	Label	Description	Also known as
English	Ornithine carbamoyltransferase	mammalian protein found in Homo sapiens	OTCase OTC ornithine transcarbamylase ornithine carbamoyltransferase, mitochondrial

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P00480

part of

Ornithine/putrescine carbamoyltransferase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P00480

Aspartate/ornithine carbamoyltransferase superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P00480

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P00480

encoded by

OTC

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P00480

molecular function

amino acid binding

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

transferase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P00480

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

carboxyl- or carbamoyltransferase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

phosphate ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

phospholipid binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

ornithine carbamoyltransferase activity

determination method

EXP

IDA

IEA

5 references

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P00480

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

24 April 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

24 April 2018

stated in

An arginine to glutamine mutation in residue 109 of human ornithine transcarbamylase completely abolishes enzymatic activity in Cos1 cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

24 April 2018

stated in

Expression of four mutant human ornithine transcarbamylase genes in cultured Cos 1 cells relates to clinical phenotypes

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

24 April 2018

stated in

Structure and Expression of a Complementary DNA for the Nuclear Coded Precursor of Human Mitochondrial Ornithine Transcarbamylase

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

EXP

ornithine carbamoyltransferase activity

determination method

EXP

IBA

IDA

IEA

6 references

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P00480

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

1 January 2018

stated in

An arginine to glutamine mutation in residue 109 of human ornithine transcarbamylase completely abolishes enzymatic activity in Cos1 cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

1 January 2018

stated in

Expression of four mutant human ornithine transcarbamylase genes in cultured Cos 1 cells relates to clinical phenotypes

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IBA

retrieved

1 January 2018

stated in

Structure and Expression of a Complementary DNA for the Nuclear Coded Precursor of Human Mitochondrial Ornithine Transcarbamylase

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

EXP

ornithine carbamoyltransferase activity

determination method

IBA

IDA

IEA

5 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P00480

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

8 April 2019

stated in

Expression of four mutant human ornithine transcarbamylase genes in cultured Cos 1 cells relates to clinical phenotypes

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

8 April 2019

stated in

An arginine to glutamine mutation in residue 109 of human ornithine transcarbamylase completely abolishes enzymatic activity in Cos1 cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IBA

cell component

cytoplasm

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

mitochondrial inner membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

mitochondrial matrix

determination method

NAS

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

TAS

retrieved

8 April 2019

stated in

Structure and Expression of a Complementary DNA for the Nuclear Coded Precursor of Human Mitochondrial Ornithine Transcarbamylase

GOA

curator

UniProt

UniProt protein ID

P00480

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

NAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P00480

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

mitochondrion

determination method

IDA

IEA

5 references

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P00480

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

24 April 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

24 April 2018

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

24 April 2018

stated in

Structure and Expression of a Complementary DNA for the Nuclear Coded Precursor of Human Mitochondrial Ornithine Transcarbamylase

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

24 April 2018

stated in

Targeting of nuclear-encoded proteins to the mitochondrial matrix: implications for human genetic defects

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IDA

mitochondrion

determination method

IBA

IDA

IEA

6 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P00480

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

8 April 2019

stated in

Targeting of nuclear-encoded proteins to the mitochondrial matrix: implications for human genetic defects

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

8 April 2019

stated in

Structure and Expression of a Complementary DNA for the Nuclear Coded Precursor of Human Mitochondrial Ornithine Transcarbamylase

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IBA

biological process

response to zinc ion

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

cellular amino acid biosynthetic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P00480

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

ornithine catabolic process

determination method

IDA

2 references

retrieved

8 April 2019

stated in

Expression of four mutant human ornithine transcarbamylase genes in cultured Cos 1 cells relates to clinical phenotypes

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

8 April 2019

stated in

An arginine to glutamine mutation in residue 109 of human ornithine transcarbamylase completely abolishes enzymatic activity in Cos1 cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IDA

midgut development

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

cellular amino acid metabolic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

response to nutrient levels

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

response to biotin

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

anion homeostasis

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

liver development

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

arginine biosynthetic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P00480

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

response to insulin

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

ammonium homeostasis

determination method

IMP

2 references

retrieved

8 April 2019

stated in

An arginine to glutamine mutation in residue 109 of human ornithine transcarbamylase completely abolishes enzymatic activity in Cos1 cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IMP

retrieved

8 April 2019

stated in

Structure of the ornithine transcarbamylase (OTC) gene and DNA diagnosis of OTC deficiency

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IMP

ornithine metabolic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

protein homotrimerization

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

urea cycle

determination method

IDA

IEA

TAS

4 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P00480

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

8 April 2019

stated in

An arginine to glutamine mutation in residue 109 of human ornithine transcarbamylase completely abolishes enzymatic activity in Cos1 cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IDA

citrulline biosynthetic process

determination method

IDA

IEA

3 references

retrieved

7 November 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

7 November 2018

stated in

Expression of four mutant human ornithine transcarbamylase genes in cultured Cos 1 cells relates to clinical phenotypes

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

7 November 2018

stated in

An arginine to glutamine mutation in residue 109 of human ornithine transcarbamylase completely abolishes enzymatic activity in Cos1 cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00480&geneProductId=UniProtKB:P00480

determination method

IDA

arginine biosynthetic process via ornithine

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IBA

citrulline biosynthetic process

determination method

IBA

IDA

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IEA

retrieved

8 April 2019

stated in

Expression of four mutant human ornithine transcarbamylase genes in cultured Cos 1 cells relates to clinical phenotypes

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

8 April 2019

stated in

An arginine to glutamine mutation in residue 109 of human ornithine transcarbamylase completely abolishes enzymatic activity in Cos1 cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00480

determination method

IBA

Gene Atlas image

PBB GE OTC 207200 at fs.png
732 × 530; 10 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P00480

1 reference

stated in

Identifiers.org

has part(s)

Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P00480

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P00480

Identifiers

RefSeq protein ID

NP_000522

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5009

XP_016885045

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5009

UniProt protein ID

P00480

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P00480

Ensembl protein ID

ENSP00000039007

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000039007

ENSP00000496606

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000496606

Freebase ID

/m/01tydx

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

2778377652

0 references

2909096189

0 references

OpenAlex ID

C2778377652

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

C2909874926

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1OTH

1 reference

stated in

UniProt

UniProt protein ID

P00480

retrieved

9 August 2016

language of work or name

English

1C9Y

1 reference

stated in

UniProt

UniProt protein ID

P00480

retrieved

9 August 2016

language of work or name

English

1EP9

1 reference

stated in

UniProt

UniProt protein ID

P00480

retrieved

9 August 2016

language of work or name

English

1FVO

1 reference

stated in

UniProt

UniProt protein ID

P00480

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(16 entries)

edit

• arwiki أورنيثين ناقل الكربامويل
• cywiki OTC
• dewiki Ornithin-Transcarbamylase
• enwiki Ornithine transcarbamylase
• eswiki Ornitina transcarbamilasa
• fawiki اورنیتین ترانس کاربامیلاز
• fiwiki Ornitiinitranskarbamylaasi
• frwiki Ornithine carbamoyltransférase
• itwiki Ornitina carbammiltransferasi
• jawiki オルニチントランスカルバミラーゼ
• lawiki Ornithini transcarbamoylasis
• ptwiki Ornitina transcarbamilase
• ruwiki Орнитинтранскарбамилаза
• shwiki Ornitin karbamoiltransferaza
• srwiki Ornitin karbamoiltransferaza
• ukwiki Орнітинкарбамоїлтрансфераза

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q420678&oldid=2022902004"