Sp1 transcription factor (Q4049840)

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mammalian protein found in Homo sapiens
  • specificity protein 1
  • transcription factor Sp1
  • SP1
  • Transcription factor Sp1 (Fragment)
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Language Label Description Also known as
English
Sp1 transcription factor
mammalian protein found in Homo sapiens
  • specificity protein 1
  • transcription factor Sp1
  • SP1
  • Transcription factor Sp1 (Fragment)

Statements

molecular function
protein binding
determination method
IPI
29 references
retrieved
8 April 2019
stated in
Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
MCAF mediates MBD1-dependent transcriptional repression
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Tau promoter confers neuronal specificity and binds Sp1 and AP-2
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Human BAHD1 promotes heterochromatic gene silencing
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
AML1-ETO interacts with Sp1 and antagonizes Sp1 transactivity through RUNT domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Wild-type p53 controls cell motility and invasion by dual regulation of MET expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Functional synergy between the transcription factor Sp1 and the estrogen receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
SH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
retrieved
8 April 2019
stated in
A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IPI
cell component
biological process
positive regulation of transcription by RNA polymerase II
determination method
IEA
IDA
IGI
IMP
TAS
11 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
TAS
retrieved
8 April 2019
stated in
Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IMP
retrieved
8 April 2019
stated in
Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IGI
retrieved
8 April 2019
stated in
miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IEA
retrieved
8 April 2019
stated in
Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IDA
retrieved
8 April 2019
stated in
Identification of Sp1-elements in the promoter region of human homeobox gene NKX3.1
GOA
curator
UniProt
UniProt protein ID
P08047
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IDA
retrieved
8 April 2019
stated in
The role of Sp1 and AP-2 in basal and protein kinase A--induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IDA
retrieved
8 April 2019
stated in
A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IDA
retrieved
8 April 2019
stated in
Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IDA
retrieved
8 April 2019
stated in
MicroRNA-29b promotes the adipogenic differentiation of human adipose tissue-derived stromal cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047
determination method
IDA
Gene Atlas image
PBB GE SP1 214732 at fs.png
732 × 530; 12 KB
0 references

Identifiers

 
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