Jagged canonical Notch ligand 1 (Q3780451)

Jagged/Serrate protein

1 reference

VWFC domain, protein family

1 reference

Notch ligand, N-terminal domain, protein family

1 reference

Delta/Serrate/lag-2 (DSL) protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2019

structural molecule activity

1 reference

9 May 2019

A non-transmembrane form of Jagged-1 regulates the formation of matrix-dependent chord-like structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

4 references

8 April 2019

Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

8 April 2019

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells

growth factor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

1 reference

9 May 2019

Flexibility of the PDZ-binding motif in the micelle-bound form of Jagged-1 cytoplasmic tail

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

5 references

9 May 2019

Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

integral component of plasma membrane

1 reference

9 May 2019

Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

1 reference

9 May 2019

Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

4 references

9 May 2019

Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

Flexibility of the PDZ-binding motif in the micelle-bound form of Jagged-1 cytoplasmic tail

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78504&geneProductId=UniProtKB:P78504

IBA

biological process

Notch signaling pathway

6 references

5 June 2018

5 June 2018

Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78504&geneProductId=UniProtKB:P78504

5 June 2018

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78504&geneProductId=UniProtKB:P78504

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78504&geneProductId=UniProtKB:P78504

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78504&geneProductId=UniProtKB:P78504

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78504&geneProductId=UniProtKB:P78504

The CD46-Jagged1 interaction is critical for human TH1 immunity

T cell mediated immunity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

negative regulation of fat cell differentiation

IMP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

loop of Henle development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

negative regulation of neuron differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

distal tubule development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

pulmonary artery morphogenesis

1 reference

9 May 2019

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

negative regulation of cell differentiation

IMP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

response to muramyl dipeptide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

ciliary body morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

nervous system development

1 reference

9 May 2019

Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

keratinocyte differentiation

1 reference

9 May 2019

Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

neuronal stem cell population maintenance

1 reference

9 May 2019

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

negative regulation of stem cell differentiation

IEP

1 reference

9 May 2019

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

blood vessel remodeling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

inner ear auditory receptor cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

positive regulation of osteoblast differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

1 reference

9 May 2019

An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

animal organ morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

cell fate determination

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

inner ear development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

endothelial cell differentiation

1 reference

9 May 2019

Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

camera-type eye development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

myoblast differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

morphogenesis of an epithelial sheet

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

positive regulation of myeloid cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

positive regulation of Notch signaling pathway

ISS

Notch signaling involved in heart development

3 references

9 May 2019

Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

negative regulation of endothelial cell differentiation

IC

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

negative regulation of cell-matrix adhesion

1 reference

9 May 2019

Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

negative regulation of cell-cell adhesion

IDA

1 reference

9 May 2019

Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

negative regulation of cell migration

IDA

1 reference

9 May 2019

Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

1 reference

9 May 2019

Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

aortic valve morphogenesis

1 reference

9 May 2019

NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

cardiac epithelial to mesenchymal transition

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78504&geneProductId=UniProtKB:P78504

Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12

ISS

Notch signaling pathway

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

positive regulation of cardiac epithelial to mesenchymal transition

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

negative regulation of Notch signaling pathway

ISS

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504

EGF-type aspartate/asparagine hydroxylation site

IBA

Gene Atlas image

PBB GE JAG1 216268 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

1 reference

EGF-like calcium-binding, conserved site

1 reference

Notch ligand, N-terminal domain

1 reference

EGF-like, conserved site

1 reference

VWFC domain

1 reference

EGF-like calcium-binding domain

1 reference

EGF-like domain

1 reference

Delta/Serrate/lag-2 (DSL) protein

1 reference

Identifiers

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

28 October 2013

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference