Death domain associated protein (Q3019283)

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mammalian protein found in Homo sapiens
  • Daxx
  • EAP1
  • Fas death domain-associated protein
  • ETS1-associated protein 1
  • hDaxx
edit
Language Label Description Also known as
English
Death domain associated protein
mammalian protein found in Homo sapiens
  • Daxx
  • EAP1
  • Fas death domain-associated protein
  • ETS1-associated protein 1
  • hDaxx

Statements

instance of
protein
0 references
molecular function
protein binding
determination method
IPI
50 references
retrieved
9 May 2019
stated in
SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies.
GOA
curator
UniProt
UniProt protein ID
Q9UER7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity
GOA
curator
UniProt
UniProt protein ID
Q9UER7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
GOA
curator
UniProt
UniProt protein ID
Q9UER7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment
GOA
curator
UniProt
UniProt protein ID
Q9UER7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Inhibition of NF-kappaB acetylation and its transcriptional activity by Daxx
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Inhibition of Daxx-mediated apoptosis by heat shock protein 27
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
DAXX is a new AIRE-interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
ATRX dysfunction induces replication defects in primary mouse cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Sequestration and inhibition of Daxx-mediated transcriptional repression by PML
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Physical and functional interactions between Daxx and STAT3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Negative modulation of androgen receptor transcriptional activity by Daxx
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Negative regulation of p53 functions by Daxx and the involvement of MDM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Daxx, a novel Fas-binding protein that activates JNK and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
FTH1 binds to Daxx and inhibits Daxx-mediated cell apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Physical and functional interactions between Daxx and TSG101
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
p14ARF interacts with DAXX: effects on HDM2 and p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Critical role for Daxx in regulating Mdm2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Daxx Silencing Sensitizes Cells to Multiple Apoptotic Pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
A Y2H-seq approach defines the human protein methyltransferase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Daxx is a key downstream component of receptor interacting protein kinase 3 mediating retinal ischemic cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
EBV tegument protein BNRF1 disrupts DAXX-ATRX to activate viral early gene transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Microspherule protein 2 associates with ASK1 and acts as a negative regulator of stress-induced ASK1 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Distinct factors control histone variant H3.3 localization at specific genomic regions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
retrieved
9 May 2019
stated in
Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IPI
cell component
nucleus
determination method
IDA
IMP
IEA
7 references
retrieved
5 June 2018
stated in
EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes
GOA
curator
UniProt
UniProt protein ID
Q9UER7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UER7&geneProductId=UniProtKB:Q9UER7
determination method
IMP
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UER7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UER7&geneProductId=UniProtKB:Q9UER7
determination method
IEA
retrieved
5 June 2018
stated in
Negative modulation of androgen receptor transcriptional activity by Daxx
GOA
curator
UniProt
UniProt protein ID
Q9UER7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UER7&geneProductId=UniProtKB:Q9UER7
determination method
IDA
retrieved
5 June 2018
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UER7&geneProductId=UniProtKB:Q9UER7
determination method
IDA
retrieved
5 June 2018
stated in
The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UER7&geneProductId=UniProtKB:Q9UER7
determination method
IDA
retrieved
5 June 2018
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UER7&geneProductId=UniProtKB:Q9UER7
determination method
IDA
retrieved
5 June 2018
stated in
Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UER7&geneProductId=UniProtKB:Q9UER7
determination method
IDA
nucleus
determination method
IDA
IEA
6 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UER7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IEA
retrieved
9 May 2019
stated in
Negative modulation of androgen receptor transcriptional activity by Daxx
GOA
curator
UniProt
UniProt protein ID
Q9UER7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IDA
retrieved
9 May 2019
stated in
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IDA
retrieved
9 May 2019
stated in
The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IDA
retrieved
9 May 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IDA
retrieved
9 May 2019
stated in
Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UER7
determination method
IDA
biological process
Gene Atlas image
PBB GE DAXX 201763 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

 
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