remdesivir (Q28209496)

https://www.clinicaltrialsarena.com/news/china-covid-19-trials/

https://www.marketwatch.com/story/these-nine-companies-are-working-on-coronavirus-treatments-or-vaccines-heres-where-things-stand-2020-03-06?mod=home-page

fórmula química

C₂₇H₃₅N₆O₈P

0 referències

SMILES canònic

Nc3ncnn2c3ccc2C(C#N)(C1O)OC(C1O)CO[P](=O)(NC(C)C(=O)OCC(CC)CC)Oc4ccccc4

0 referències

SMILES isomèric

CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4

0 referències

efecte secundari

hepatotoxicitat

naturalesa de la declaració

sovint

1 referència

https://www.biospace.com/article/data-from-gilead-s-compassionate-use-of-remdesivir-for-covid-19-looks-promising/

malaltia tractada

COVID-19

disputat per

Organització Mundial de la Salut

1 referència

https://www.nbcnews.com/health/health-news/remdesivir-shouldn-t-be-used-hospitalized-covid-19-patients-who-n1248320

22 gen 2022

febre hemorràgica de l'Ebola

The antiviral remdesivir should not be used as treatment for hospitalized Covid-19 patients, the World Health Organization said Thursday, only a month after the Food and Drug Administration approved the drug to treat patients over age 12 who are hospitalized with Covid-19. (anglès)

1 referència

https://www.drugsincontext.com/the-journey-of-remdesivir:-from-ebola-to-covid-19/

22 gen 2022

estatuts legal (medicina)

Although remdesivir performed well in preclinical studies, it did not meet efficacy endpoints in a randomized trial conducted during an Ebola outbreak. (anglès)

mode d'administració

teràpia intravenosa

0 referències

boxed warning ^anglès

1 referència

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

títol

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (anglès)

descrit a l'URL

https://pubmed.ncbi.nlm.nih.gov/34252308/

0 referències

https://github.com/croningp/ChemputerAntiviralXDL/tree/master/Remdesivir

1 referència

https://twitter.com/Chemputation/status/1255645127281979397

es caracteritza per

ineffective drug ^anglès

afirmació sostinguda per

Organització Mundial de la Salut

20 nov 2020

2 referències

https://www.who.int/news-room/feature-stories/detail/who-recommends-against-the-use-of-remdesivir-in-covid-19-patients

22 gen 2022

WHO has issued a conditional recommendation against the use of remdesivir in hospitalized patients, regardless of disease severity, as there is currently no evidence that remdesivir improves survival and other outcomes in these patients. (anglès)

https://pubmed.ncbi.nlm.nih.gov/34252308/

22 gen 2022

febre hemorràgica de l'Ebola

However, the clinical efficacy of remdesivir for COVID-19 remains contentious, as several trials have not found statistically significant differences in either time to clinical improvement or mortality between remdesivir-treated and control groups. (anglès)

ineffective drug ^anglès

malaltia tractada

1 referència

https://www.drugsincontext.com/the-journey-of-remdesivir:-from-ebola-to-covid-19/

22 gen 2022