Colony stimulating factor 2 (Q423660)

From Wikidata

(Redirected from Q14865496)

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

• CSF2
• granulocyte macrophage-colony stimulating factor
• colony stimulating factor 2 (granulocyte-macrophage)
• Colony-stimulating factor
• granulocyte-macrophage colony-stimulating factor
• CSF

edit

Language	Label	Description	Also known as
English	Colony stimulating factor 2	mammalian protein found in Homo sapiens	CSF2 granulocyte macrophage-colony stimulating factor colony stimulating factor 2 (granulocyte-macrophage) Colony-stimulating factor granulocyte-macrophage colony-stimulating factor CSF

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P04141

part of

granulocyte-macrophage colony-stimulating factor

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P04141

four-helical cytokine-like, core

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P04141

image

GMCSF Crystal Structure.rsh.png
900 × 750; 236 KB

media legend

Structure cristalline du GM-CSF telle que publiée dans la Protein Data Bank (French)

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P04141

encoded by

CSF2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P04141

molecular function

growth factor activity

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

granulocyte macrophage colony-stimulating factor receptor binding

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

The human gene encoding GM-CSF is at 5q21-q32, the chromosome region deleted in the 5q- anomaly

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

protein binding

determination method

IPI

3 references

retrieved

8 April 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IPI

retrieved

8 April 2019

stated in

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IPI

retrieved

8 April 2019

stated in

Widespread macromolecular interaction perturbations in human genetic disorders

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IPI

protein tyrosine kinase activity

determination method

TAS

1 reference

retrieved

10 September 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04141&geneProductId=UniProtKB:P04141

determination method

TAS

cytokine activity

determination method

IDA

IEA

3 references

retrieved

27 March 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04141&geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

27 March 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04141&geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

27 March 2018

stated in

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04141&geneProductId=UniProtKB:P04141

determination method

IDA

cytokine activity

determination method

IBA

IDA

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IBA

cell component

extracellular region

determination method

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

intracellular membrane-bounded organelle

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

extracellular space

determination method

IDA

IEA

3 references

retrieved

27 March 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04141&geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

27 March 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04141&geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

27 March 2018

stated in

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04141&geneProductId=UniProtKB:P04141

determination method

IDA

extracellular space

determination method

IBA

IDA

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IBA

biological process

negative regulation of cytolysis

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

positive regulation of macrophage derived foam cell differentiation

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

regulation of cell population proliferation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

MAPK cascade

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

TAS

positive regulation of podosome assembly

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

positive regulation of interleukin-23 production

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

positive regulation of gene expression

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

embryonic placenta development

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

epithelial fluid transport

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

regulation of gene expression

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

dendritic cell differentiation

determination method

IEA

IDA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

GOA

curator

Developmental FunctionaL Annotation at Tufts

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

myeloid dendritic cell differentiation

determination method

IEA

IDA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

Galectin-9 induces maturation of human monocyte-derived dendritic cells

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

macrophage activation

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

cellular response to lipopolysaccharide

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

immune response

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

monocyte differentiation

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

response to fluid shear stress

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

response to silicon dioxide

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

neutrophil differentiation

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

peptidyl-tyrosine phosphorylation

determination method

IEA

1 reference

retrieved

10 September 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04141&geneProductId=UniProtKB:P04141

determination method

IEA

regulation of circadian sleep/wake cycle, sleep

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

histamine secretion

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

positive regulation of tyrosine phosphorylation of STAT protein

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Insulin-like growth factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

cellular response to granulocyte macrophage colony-stimulating factor stimulus

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

regulation of myeloid cell differentiation

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

TAS

regulation of signaling receptor activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

negative regulation of transcription, DNA-templated

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

GOA

curator

UniProt

UniProt protein ID

P04141

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

cytokine-mediated signaling pathway

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

TAS

positive regulation of cell population proliferation

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

Insulin-like growth factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

neutrophil differentiation

determination method

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IBA

monocyte differentiation

determination method

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IBA

macrophage differentiation

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection

GOA

curator

ARUK-UCL

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IDA

macrophage activation

determination method

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04141

determination method

IBA

Gene Atlas image

PBB GE CSF2 210229 s at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P04141

1 reference

stated in

Identifiers.org

different from

sargramostim

0 references

Identifiers

CAS Registry Number

83869-56-1

1 reference

stated in

SciFinder

retrieved

19 October 2015

RefSeq protein ID

NP_000749

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1437

UniProt protein ID

P04141

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P04141

Ensembl protein ID

ENSP00000296871

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000296871

Freebase ID

/m/064r2c

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

2777478134

0 references

OpenAlex ID

C2777478134

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1CSG

1 reference

stated in

UniProt

UniProt protein ID

P04141

retrieved

9 August 2016

language of work or name

English

2GMF

1 reference

stated in

UniProt

UniProt protein ID

P04141

retrieved

9 August 2016

language of work or name

English

4NKQ

1 reference

stated in

UniProt

UniProt protein ID

P04141

retrieved

9 August 2016

language of work or name

English

5C7X

1 reference

stated in

UniProt

UniProt protein ID

P04141

retrieved

9 August 2016

language of work or name

English

5D70

1 reference

stated in

UniProt

UniProt protein ID

P04141

retrieved

9 August 2016

language of work or name

English

5D71

1 reference

stated in

UniProt

UniProt protein ID

P04141

retrieved

9 August 2016

language of work or name

English

5D72

1 reference

stated in

UniProt

UniProt protein ID

P04141

retrieved

9 August 2016

language of work or name

English

4RS1

1 reference

stated in

UniProt

UniProt protein ID

P04141

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(18 entries)

edit

• arwiki عامل منبه لمستعمرات المحببات والبلاعم
• cawiki Factor estimulant de colònies de granulòcits i macròfags
• cywiki CSF2
• dewiki GM-CSF
• enwiki Granulocyte-macrophage colony-stimulating factor
• eswiki Factor estimulante de colonias de granulocitos y macrófagos
• frwiki Facteur stimulant les colonies de granulocytes et de macrophages
• glwiki Factor estimulante de colonias de granulocitos-macrófagos
• idwiki Faktor stimulasi koloni makrofaga granulosit
• jawiki 顆粒球マクロファージコロニー刺激因子
• kowiki 과립구 대식세포 콜로니 자극 인자
• plwiki Czynnik stymulujący tworzenie kolonii granulocytów i makrofagów
• ruwiki Гранулоцитарно-макрофагальный колониестимулирующий фактор
• slwiki Granulocitno-makrofagne kolonije stimulirajoči faktor
• trwiki Granülosit makrofaj koloni uyarıcı faktör
• ukwiki CSF2
• viwiki Yếu tố kích thích dòng bạch cầu hạt - đại thực bào
• zhwiki 粒细胞-巨噬细胞集落刺激因子

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q423660&oldid=2022902234"